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Why medication sometimes doesn't help, why a B-complex can worsen depression, why postpartum depression is often linked to copper overload, or why your results are "within normal range" yet you still don't feel well — the answers are grounded in the orthomolecular approach and published research.
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Histamine in the brain
Histamine isn't just about allergies. In the brain it acts as a neurotransmitter, and its blood level splits people with depression into two completely different groups — histadelics and histapenics.
Read articleScientific review of SSRI effects
A brief overview of published research on how SSRIs change brain neurochemistry (serotonin, dopamine, oxytocin) and what a realistic recovery timeline looks like after discontinuation. The full review, with 20 sections and PubMed citations, is on a dedicated page.
Read articleScientific authority
A short biography of the three people who laid the foundation of orthomolecular psychiatry: Linus Pauling (1968), Carl C. Pfeiffer (Brain Bio Center, Princeton), and William J. Walsh (Walsh Research Institute, 30,000+ patients).
Read articleThe Walsh paradox
One of the most surprising scientific findings: the very same vitamin (folate / folic acid) helps one depression biotype and worsens another. Why, and how to tell them apart.
Read articleBiotype 2 vs. Biotype 3
The most classic mistake in psychiatry: histadelia and histapenia have similar symptoms (anxiety, depression) but completely opposite biochemistry, requiring opposite nutritional approaches. The same medication that improves one will worsen the other.
Read articlePractical guide
The Pyroluria test (morning urine) is accurate — but only if you prepare for it correctly. The 7 days before collection matter more than the test itself. Here is the complete checklist.
Read articleAntidepressants and methylation
Antidepressants are commonly chosen by trial and error. Walsh's data show that response to a specific drug can be predicted by a single biochemical parameter: methylation status. We explain why, and how it can be measured.
Read articleAdvanced methylation diagnostics
Dr. Walsh used total whole-blood histamine as the primary methylation marker for decades. Newer panels (SAM, SAH, SAM/SAH ratio) measure methylation more directly. When histamine testing is enough, and when it's worth going deeper.
Read articleMethylation basics
Methylation is one of the most important processes in the human body. It governs neurotransmitters, histamine breakdown, gene expression, and how you experience stress. Here is an explanation that needs no biochemistry background.
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