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Why medication sometimes doesn't help, why a B-complex can worsen depression, why postpartum depression is often linked to copper overload, or why your results are "within normal range" yet you still don't feel well — the answers are grounded in the orthomolecular approach and published research.
Latest articles
Copper overload
Anxiety, exhaustion, hormonal swings and blood work that comes back “normal”. Some orthomolecular authors link this picture to copper that builds up in tissues in a form the body cannot use. Here is what the term means, where it comes from, and how much of it can actually be verified.
Read articleDepression with no results
A guide for people who have taken antidepressants for years with no clear benefit. The five biochemical types of depression under the orthomolecular approach — and how to find out which one applies to you.
Read articleThe orthomolecular approach explained
Pfeiffer and Walsh showed that depression isn't a single condition. Five different biochemical patterns need five different approaches. Here's each one explained in plain terms.
Read articlePyroluria — biotype 1
Pyroluria is a metabolic disorder in which the body loses zinc and vitamin B6 through urine. It affects up to 15% of the population and can look like anxiety, depression, burnout, or just "sensitivity" to everything.
Read articleThe MTHFR myth
In recent years it's become common to hear that everyone with depression needs folate or methylfolate. Walsh's data show the opposite — for one of the five biotypes, folate can make depression worse.
Read articleHistapenia and anxiety
High anxiety, panic, paranoid thoughts. SSRIs made you worse. With overmethylation, this picture has a specific biochemical explanation and calls for the opposite nutritional approach from the classic depression profile.
Read articlePostpartum depression and copper
In 95% of cases, postpartum depression has a measurable biochemical finding — elevated serum copper. Estrogen retains copper, and copper shifts neurotransmitter balance. This isn't "just hormones."
Read articleCortisol and burnout
Morning fatigue and evening wired-ness aren't "laziness." They are signs of a disrupted cortisol rhythm — a burned-out stress axis that can be objectively measured from saliva.
Read articleThe history of orthomolecular psychiatry
Five researchers who connected brain biochemistry to targeted nutritional treatment. From Nobel laureate Linus Pauling to William Walsh and his database of 30,000 patients.
Read articleDiscontinuing psychiatric medication
Davies and Read (2019), in a systematic review, showed that 56% of patients experience withdrawal symptoms when stopping antidepressants, and for 46% those symptoms are severe. Safe discontinuation is always gradual, often taking many months, and done in cooperation with the prescribing physician. This article explains why — with references to PubMed studies.
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