Histamine Test (whole blood) — €149
Recommended first test for this path.
See the test Order directly →Biotype 2 — Histadelia
Histadelia (undermethylation, high histamine)
High-achiever, perfectionist type. Depression since youth — maybe since school. SSRIs helped somewhat, but folate or "healthy" B-complexes make things worse. Family often has unusually high-achieving members, or, conversely, addiction.
Read more: Histamine and Mental Health — the Neurotransmitter People Forget About
Is this me?
When this path makes sense
Histadelia ("undermethylation" in the English-language literature) is a biotype marked by excess histamine in the blood and a relative shortage of methyl groups in the central nervous system. Walsh's data shows this state increases activity of the serotonin transporter (SERT), which clears serotonin from the synapse too quickly. The brain ends up functionally low on serotonin — even though it is produced in normal amounts. In this profile, SSRIs have been observed to work better under the Walsh model — a doctor always decides on the suitability and effectiveness of treatment. **A high folate intake can make symptoms worse for some people** (discuss any change in supplementation with your doctor) — it raises SERT activity independently of methylation. So "healthy" B-complexes or heavy leafy-green intake can, paradoxically, worsen depression in people with histadelia. Clinically: long-standing depression since youth, perfectionism, obsessive thinking, seasonal allergies, strong willpower, high-achiever type. Family history often includes addiction or suicidal tendencies.
Obsessions
Seasonal depression
Inner tension
Allergies
Anger / irritability
Perfectionism
Rumination
Headaches
Next step
Start with a test, not guesswork.
This path isn't about buying five supplements right away. First confirm the area that best matches your symptoms. Only then does it make sense to act on the result with supplements or a consultation.
After the result
What's worth addressing next
The test is only the start — the real value comes once you pair the result with a consultation and targeted nutritional support for your biotype. Here are the usual next steps.
Path
Practical plan
- Fill in the orientational screening — it checks whether your symptoms are compatible with this biotype.
- Order the Histamine Test (€149) — the sample is collected at home or at a local laboratory.
- Once the result is in, targeted nutritional support (Histamin Minus) is handled in the Consultation with a Doctor / Therapist (€149).