"I have depression and medication isn't helping."
You've been on antidepressants for years, but no one ever asked about your brain biochemistry. You may have a type of depression that folate or SSRIs won't help — because the cause lies elsewhere.
Orthomolecular approach · pyroluria
Mental health care from the comfort of your home
No guessing here. We measure.
Depression, anxiety, or chronic fatigue can have a measurable biochemical cause that a 15-minute psychiatric check-up will never uncover. PsyLab walks you, step by step, from identifying your symptoms to lab testing, interpreting the results, and targeted nutritional support — no guesswork, no more blind prescriptions.
Pfeiffer Walsh Hoffer Pauling urine · blood · saliva · hair
Does any of this sound familiar?
These are the sentences we hear from clients, year after year.
If you recognize yourself in any of these situations, you're not alone. And you're probably not a "treatment-resistant case" — you may simply belong to a biochemical biotype that standard psychiatry rarely investigates.
"Stress wrecks me faster than it does other people."
Sensitivity to noise, light, supplements. Stress puts you out of action for days. You don't remember your dreams. That's not weakness — it could be pyroluria, measurable from urine.
"I have anxiety and panic disorder."
SSRIs made things worse and common advice doesn't work. In histapenia (overmethylation), high anxiety is a direct result of a biochemical imbalance — and calls for the opposite nutritional approach to the classic depression profile.
"Everything fell apart after giving birth."
According to the orthomolecular approach, postpartum depression can be linked to elevated copper levels, affected by hormonal changes after birth. An orientation questionnaire can help you find out if that may be your case.
"I have brain fog I never used to have."
After an infection, vaccination, prolonged stress, or time spent in a mouldy environment. You may have a toxic burden — a hair mineral analysis can confirm or rule it out.
"Supplements and B-complex made me worse."
Not every supplement is right for you. Under the orthomolecular approach, a high folate intake in undermethylation can, for some people, subjectively worsen symptoms — always discuss any change in supplementation first.
Which pattern actually fits you?
Find out in 5 minutesWhy no one addressed this before
Conventional psychiatry looks at symptoms. The orthomolecular approach looks at biochemistry.
Standard diagnosis of depression or anxiety is based on subjective questions — with no blood, urine, or biochemical markers involved. The result is a label (depression, GAD, BPD) and a prescription for an SSRI or a benzodiazepine. If it doesn't help, you get a different medication. Then another.
Walsh's research on more than 30,000 patients showed that most psychiatric disorders have a measurable biochemical basis — abnormalities in methylation, in the copper-to-zinc ratio, in histamine levels, or in urinary pyrrole content. What we call "depression" is actually at least five different biochemical types, each needing a different approach.
Five biochemical types of depression
- 1 — Pyroluria · low stress tolerance, sensitivity, exhaustion
- 2 — Histadelia (undermethylation) · obsessive thoughts, perfectionism, seasonal allergies
- 3 — Histapenia (overmethylation) · high anxiety, panic, paranoid states
- 4 — Copper overload · postpartum depression, hormonal swings, ADHD
- 5 — Heavy metals · chemical sensitivity, brain fog, moldy environments
Each of these types has its own lab marker — and its own targeted nutritional support.
How the whole process works
From "I don't know what's wrong with me" to a concrete test.
No more blind supplements or blind prescriptions. First you find out which biochemical pattern is most likely behind your struggles, then you confirm it with a lab test, and only then do you choose targeted support.
Orientation questionnaire
A free 5-minute questionnaire based on the orthomolecular approach. It identifies which of the five biotypes most likely matches your symptoms.
Start the questionnaire →Lab test
Depending on your biotype, you order a specific test: Pyroluria from urine (€99), Histamine from blood (€149), Cortisol from saliva (€149), or a heavy metals hair analysis (€199).
See the tests →Consultation (45 min)
After your test result, a 45-minute consultation (€75) explains your result and goes through the options for next steps. Online or by phone.
Book a consultation →Targeted nutritional support
Nutritional support tailored to your specific biotype — for example zinc and vitamin B6, or a freeze-dried bovine adrenal complex. Citrate-free, vegan variants available, made in the EU.
See the vitamins →Five biochemical biotypes
Choose the biotype you recognize yourself in best.
Each biotype has its own typical picture, recommended test, and targeted nutritional support.
Biotype 1 — Pyroluria
Pyroluria (B6, zinc and manganese deficiency)
People who feel stress wears them down faster than it does other people. Sensitive to noise, light, medications and supplements.
See this biotype →Biotype 2 — Histadelia
Histadelia (undermethylation, high histamine)
High-achiever, perfectionist type. Depression since youth — maybe since school.
See this biotype →Biotype 3 — Histapenia
Histapenia (overmethylation, low histamine)
High anxiety, panic, possibly paranoid thoughts. You've tried SSRIs and they made things worse.
See this biotype →Biotype 4 — Copper overload
Copper overload (adrenal exhaustion, anxious depression)
Symptoms appeared after childbirth, or worsen around the menstrual cycle, ovulation, or during menopause. Can't get going in the morning, can't switch off at night.
See this biotype →Biotype 5 — Heavy metals
Toxic heavy-metal overload
You used to live in a damp or moldy building. Everything got worse after an infection.
See this biotype →Biotype · test · vitamin mapping
One test, one vitamin for every biotype.
5 biotypes, 3 main tests + 3 complementary tests (heavy metals, thyroid, vitamins & minerals), 6 vitamins + a 45-min consultation (€75). No bundles, no surprises — just targeted testing and nutritional support.
Main test 🧫 Pyroluria Test €99
Recommended nutrients 💊 Stress Support
Main test 🩸 Histamine Test €149
Main test ⚗️ Cortisol Test €149
Recommended nutrients 💊 Bovine Adrenal Complex
Complementary test 🧪 Heavy Metal & Mineral Analysis €199
Recommended nutrients 💊 Stress Support
Complementary test 🦋 Thyroid Test €149
Recommended nutrients 🦋 Bovine Thyroid Complex
Complementary test 🩺 Vitamin & Mineral Test €199
Recommended nutrients Based on the result — handled in the doctor consultation
From the blog
Answers to common questions about mental health biochemistry.
Depression with no results
I have depression and antidepressants aren't helping — what now?
A guide for people who have taken antidepressants for years with no clear benefit. The five biochemical types of depression under the orthomolecular approach — and how to find out which one applies to you.
The orthomolecular approach explained
The five biochemical types of depression under the orthomolecular approach
Pfeiffer and Walsh showed that depression isn't a single condition. Five different biochemical patterns need five different approaches. Here's each one explained in plain terms.
Pyroluria — biotype 1
Pyroluria — the metabolic imbalance that isn't taught in mainstream psychiatry
Pyroluria is a metabolic disorder in which the body loses zinc and vitamin B6 through urine. It affects up to 15% of the population and can look like anxiety, depression, burnout, or just "sensitivity" to everything.
The MTHFR myth
Folate can worsen depression — in which people, and why
In recent years it's become common to hear that everyone with depression needs folate or methylfolate. Walsh's data show the opposite — for one of the five biotypes, folate can make depression worse.
Histapenia and anxiety
Anxiety and panic that SSRIs don't fix — an orthomolecular view
High anxiety, panic, paranoid thoughts. SSRIs made you worse. With overmethylation, this picture has a specific biochemical explanation and calls for the opposite nutritional approach from the classic depression profile.
Postpartum depression and copper
Postpartum depression: why it isn't just "hormones" — and what to do about it
In 95% of cases, postpartum depression has a measurable biochemical finding — elevated serum copper. Estrogen retains copper, and copper shifts neurotransmitter balance. This isn't "just hormones."
You don't have to guess. Your biochemistry can be measured.
Start with the free screening. In a few minutes, you'll get a likely biotype, a recommended test, and a concrete next step. No sign-ups, no email spam, no upsells.
Start the free screening